October 2021
Intermediate to advanced
352 pages
9h 14m
English
book
Computation in BioInformatics
by S. Balamurugan, Anand T. Krishnan, Dinesh Goyal, Balakumar Chandrasekaran, Boomi Pandi
Content preview from Computation in BioInformatics
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5In Silico Protein Design and Virtual Screening
Vivek P. Chavda3, Zeel Patel1*, Yashti Parmar2 and Disha Chavda4
1Department of Electromechanical, Sheridan Collage of Engineering, Toronto, Canada
2Department of Pharmacology and Medicines, Weifang Medical University, Shandong, China
3Formulation & Development, Dr. Reddy’s Laboratory (Biotech division), Hyderabad, India
4Analytical Development, Orbicular Pharmaceutical Ltd, Hyderabad, India
Abstract
If we look back in the last decade, there are so many achievements been made in the field of molecular biology and computational design to make functional modification of proteins a reality. The journey so far is really long and being cherished from structure based virtual screening (SBVS) which is used at early-stage drug discovery for finding the actual reason of Mutagenesis or even improvement of protein purity and quality. Docking-based virtual screening is most widely used nowadays followed by high-throughput screening. Virtual screening is basically a screening tool at the early phase of drug discovery for sequence selection considering desired protein function. These technological advancements have brought the cost of drug discovery down along with tremendous speed and control over the protein design part which brings the artificial proteins engineering at an evolutionary phase. Software packages for in silico protein design have been engineered for the academic usage.
Keywords: Protein design, docking, in silico, virtual ...
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