Essentials of Molecular Biology

6

Protein Sorting

CONCEPT OUTLINE

• Introduction
• Signal Sequences
• Tanslocation of Secretory Proteins Across the ER
  • The signal sequences of secretory proteins to ER
  • The signal recognition particle
  • SRP receptor
  • Translocation into the ER lumen
  • Insertion of proteins into the ER membrane
  • GPI-anchored proteins
• Protein Modifications in the ER
  • Protein glycosylation
  • Disulphide bond formation
  • The role of N-linked glycosylation in ER protein folding
• Protein Targeting to Mitochondria and Chloroplast
  • Transport of proteins to mitochondria
  • Transport of proteins to chloroplast
• Protein Targeting to the Nucleus
  • Nuclear localization signals
  • Transport of proteins into the nucleus
  • Transport of proteins out of the nucleus
  • Transport and Sorting of Proteins ...