Integrated Microsystems

26Two-Dimensional Microfluidic Bioarray for Nucleic Acid Analysis

Lin Wang

Paul C.H. Li

CONTENTS

1. 26.1 Introduction to Microfluidic DNA Microarray Hybridization
2. 26.2 Microfluidic DNA Hybridization with Low-Density Probe Arrays
   1. 26.2.1 The Low-Density Microfluidic Microarray Method with Pin-Spotted Probes
   2. 26.2.2 The Low-Density Microfluidic Microarray Method with the Two-Dimensional (2D) Intersection Approach
   3. 26.2.3 High-Throughput Parallel Hybridization with Centrifugal Force-Driven Microflows
3. 26.3 Summary and Conclusions
4. References

26.1 Introduction to Microfluidic DNA Microarray Hybridization

Nucleic acid hybridization techniques feature the use of a probe nucleic acid molecule to detect a target nucleic acid molecule. Here, probe molecules ...