Integrated Microsystems

27Microfluidic Systems to Study the Biology of Human Diseases and Identify Potential Therapeutic Targets in Caenorhabditis elegans

Pouya Rezai

Sangeena Salam

P. Ravi Selvaganapathy

Bhagwati P. Gupta

CONTENTS

1. 27.1 Introduction
2. 27.2 Animal Models to Study Human Diseases
   1. 27.2.1 Cultured Cells and Eukaryotes
   2. 27.2.2 The Nematode C. elegans
      1. 27.2.2.1 Development and Behavior
      2. 27.2.2.2 Conservation of Biological Processes
3. 27.3 C. elegans as a Model for Studying Neurodegenerative and Movement Disorders and Screen for Drug Candidates
   1. 27.3.1 Muscle Disorders
   2. 27.3.2 Neurodegenerative Diseases
      1. 27.3.2.1 Alzheimer’s Disease
      2. 27.3.2.2 Huntington’s Disease
      3. 27.3.2.3 Parkinson’s Disease
4. 27.4 High-Throughput and Automated Techniques to Manipulate C. elegans ...