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Chapter 15
Example: Target
Selection Based on
Protein Network
Analysis
O
critical early decisions in the drug discovery process
is the correct target to go aer with a molecule. Typically, the target
will be a particular protein on a cell type involved in the disease. e dif-
culty is in determining which target protein to choose.
Gene expression information taken from large population studies of
people who have a given disease can be somewhat helpful in determining
a set of candidate proteins. Yet seldom do such statistical studies reveal a
single genetic culprit. Instead, gene studies oen nd hundreds of genes to
be signic ...