Genetics for Nurses

Table of contents

1. Cover
2. Title Page
3. Contents
4. About the Author
5. Dedication
6. Foreword
7. Preface
8. 1. Practical Application of Genetics in Nursing and Roles of a Nurse
   1. Roles of a Nurse
   2. Career Focus
   3. Review Question
9. 2. Review of Cellular Division: Mitosis and Meiosis
   1. Introduction to Prokaryotic and Eukaryotic Cell
   2. Cell Division
   3. An Overview of the Cell Cycle
   4. The Mechanics of Cell Division
   5. Mitosis in Detail
   6. Meiosis
   7. Review Questions
10. 3. Structure and Organization of Genetic Material
    1. Characteristics and Structure of DNA and Chromosomes—DNA Packaging and Chromosome Condensation
    2. Chromosomes and Sex Determination
    3. Review Questions
11. 4. Errors in Transmission
    1. Overview of Chromosome Morphology
    2. Review Questions
12. 5. Classical Genetics: Mendelian Theory of Inheritance
    1. Principles of Genetics: Mendelian Principles,
    2. Mendel’s Experimental Organism: The Pea Plant
    3. Mendel’s Experiment: Monohybrid and Dihybrid Crosses
    4. Review Questions
13. 6. Patterns and Mechanisms of Inheritance in Humans
    1. Pedigree
    2. Patterns of Inheritance in Humans
    3. Review Questions
14. 7. Multiple Alleles and Blood Groups
    1. The ABO Blood Group
    2. Function of IA, I B and i Alleles of the ABO Gene
    3. Other Genetic Systems that Exhibit Multiple Allelism
    4. Review Questions
15. 8. Prenatal Nutrition
    1. Maternal Nutritional Status
    2. Food Allergies
    3. Review Questions
16. 9. Conditions Affecting the Mother
    1. Infections during Pregnancy
    2. Effect of Drugs, Chemicals and Radiation
    3. Maternal Drug Therapy
    4. Review Questions
17. 10. Genetic Testing and Diagnosis
    1. Newborn Screening
    2. Heterozygote Screening
    3. Presymptomatic Testing
    4. Prenatal Genetic Testing and Diagnosis
    5. Indications for Prenatal Diagnosis (PND)
    6. Methods of Prenatal Diagnosis
    7. Principles of Screening Tests
    8. Non-invasive Testing
    9. Invasive Testing
    10. Review Questions
18. 11. Impact of Genetic Condition on Families and Genetic Counselling
    1. Impact of Genetic Condition on Families
    2. Genetic Counselling
    3. Review Questions
19. 12. Consanguinity
    1. Consanguineous Marriage and Risk of Inheriting Genetic Disorder
    2. Review Questions
20. 13. Advanced Maternal Age
    1. Aneuploidies and Advanced Maternal Age
    2. Autosomal Aneuploidies
    3. Sex Chromosome Aneuploidies
    4. Review Questions
21. 14. Down Syndrome (Trisomy 21)
    1. Overview
    2. Genetics of Down Syndrome
    3. Advanced Maternal Age in Down Syndrome
    4. Characteristic Features/Phenotype of Down Syndrome
    5. Medical Conditions Associated with Down Syndrome
    6. Down Syndrome Management
    7. Down Syndrome Diagnosis
    8. Review Questions
22. 15. Infertility
    1. Factors Affecting Fertility
    2. Causes of Subfertility—Male and Female Subfertility
    3. Male Subfertility
    4. Female Subfertility
    5. Assisted Reproductive Techniques
    6. Review Questions
23. 16. Spontaneous Abortion
    1. Definition
    2. Pathophysiology
    3. Mechanism of Abortion
    4. Incidence
    5. Clinical Types of Abortion
    6. Risk of Recurrent Pregnancy Loss
    7. Factors Involved in Recurrent Early Pregnancy Loss
    8. Genetic Factors
    9. Non-genetic Factors
    10. Miscellaneous Factors
    11. Indian Scenario
    12. Review Questions
24. 17. Congenital Abnormalities, Dysmorphism, and Developmental Delay
    1. Congenital Abnormalities (Birth Defects) and Dysmorphology
    2. Clinical Dysmorphology—Classification of Foetal and Birth Defects
    3. Diagnostic Approach to the Dysmorphic Foetus
    4. Teratology
    5. Basic Principles of Teratology
    6. Developmental Milestones
    7. Review Questions
25. 18. Neural Tube Defects
    1. Screening of NTD with Maternal Serum Alpha-Fetoprotein (AFP)
    2. Ultrasound Evaluation of NTDs
    3. Prevention of NTD
    4. Genetic Susceptibility for NTD and Folic Acid Intake
    5. Fortification during Pregnancy
    6. Review Questions
26. 19. The Nature of Cancer
    1. Cancer as a Genetic Disease
    2. DNA Repair Genes
    3. Chromosome Mutations and Cancer
    4. The Molecular Genetics of Colorectal Cancer
    5. Review Questions
27. 20. Inborn Errors of Metabolism
    1. Classification of Inherited Metabolic Diseases
    2. Enzyme Defects (Aminoacidopathies)
    3. Defects in Purine Metabolism (Lesch Nyhan Syndrome)
    4. Lysosomal Storage Diseases
28. 21. Haematological Disorders and Genetic Haemochromatosis
    1. Genetic Haemochromatosis (GH)
    2. Review Questions
29. 22. Mental Illness/Mental Disorder
    1. Normal Mental Health
    2. Review Questions
30. 23. The Human Genome Project
    1. Institutes Involved
    2. Supported By
    3. Budget
    4. Goals (Adapted from the Human Genome Project Report)
    5. Milestones
    6. Samples
    7. Vectors Used
    8. Sequencing
    9. Findings (Adapted from the Human Genome Project Report)
    10. Current Applications
    11. Ethical, Social and Legal Implications
    12. Review Questions
31. 24. Gene Therapy
    1. Types
    2. Classification Based on Type of Therapy
    3. Classification Based on the Method of Therapy
    4. Vectors Used
    5. Non-viral Vector Systems
    6. Special Gene Therapy Strategies
    7. Review Questions
32. 25. Eugenics Movement
    1. Positive and Negative Eugenics
    2. Review Questions
33. 26. Legal and Ethical Issues
    1. Ethical Issues in Prenatal Diagnosis (Adapted from WHO Guidelines on Ethical Issues in Medical Genetics
    2. Ethical Issues in Genetic Testing of Children
    3. Privacy of Genetic Information and Its Misuse
    4. Review Questions
34. Case Studies
35. Illustrations
36. Acknowledgements
37. Copyright