Bioinformatics with Python Cookbook

Plotting protein interactions with Cytoscape the hard way

Cytoscape (http://cytoscape.org/) is a platform to visualize molecular interaction networks. Here, we will interact with Cytoscape using a REST interface. There are easier ways to perform this recipe, but we will take this opportunity to continue interacting with the PSICQUIC service. Also, we will exercise the NetworkX graph processing library (https://networkx.github.io/), which will be useful on its own.

Taking a page from Chapter 7, Using the Protein Data Bank, we will plot p53 interactions stored in the UniProt database.

Getting ready

You will need to install the Cytoscape version 3.2.1 (or higher), which will require Java 7 or preferably 8. You will also need the cyREST application ...