5.1 Introduction: Cybersecurity and Manufacturing Industry 4.0 in the Fourth Industrial Revolution5.2 Significant Cybersecurity Challenges in Manufacturing Industry 4.05.3 Increased Attack Surface5.4 Legacy Systems and Insecure Networks5.5 Third Industrial Revolution Machine Control Systems – Industrial Control Systems and Supervisory Control and Data Acquisition Security5.6 Supply Chain Vulnerabilities5.7 Virus5.8 Types of Malwares5.9 Data Privacy and Intellectual Property Protection5.10 Insider Threats5.11 Challenging Stint for Cybersecurity in Manufacturing Industry 4.05.12 Self-Tuning Model5.13 Self-Tuning Model Application and Functionality5.14 Self-Tuning Model and Industry 4.05.15 Applications for Self-Tuning Models in Manufacturing Industry 4.05.16 Self-Tuning Model and Cybersecurity5.17 Digital Immune System5.18 Key Roles of Cybersecurity in the Digital Immune System5.19 Self-Tuning Model Integrated into a Digital Immune System5.20 Proposed Digital Immune Model5.21 Conceptual Model Integrating Digital Immune Systems, Self-Tuning Models, Cybersecurity, and Manufacturing Industry 4.05.22 Interdependence of Cybersecurity, Self-Tuning Model, and Digital Immune System5.23 ConclusionReferences