April 2019
Intermediate to advanced
480 pages
16h 38m
English
Content preview from High Value Fermentation Products, Volume 1
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Chapter 3Antibiotics Against Gram Positive Bacteria
Rahul Vikram Singh, Hitesh Sharma, Anshela Koul and Vikash Babu*
Fermentation Technology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001 (India)
*Corresponding author: vikash@iiim.ac.in
Abstract
The role of microbial products as a source of remedies for the treatment of various diseases has been accepted since ancient times. Among these microbial products, antibiotics are the potential compounds for the treatment of life-threatening diseases. Due to bacterial drug resistance, demand for new antibiotics has been increasing; therefore, researchers are putting their attention on synthesizing the derivative of drug molecules in the laboratory so that the biological activity can be evaluated. For the treatment of infections caused by Gram positive bacteria, cephalosporins and penicillins are the largest-selling antibiotics globally. Both of these antibiotics contain the “β-lactam” ring which is responsible for inhibiting cell wall synthesis of pathogens. In this chapter, different type of antibiotics, their mode of action, application and fermentation production process are discussed.
Keywords: Gram positive bacteria, Cephalosporins, Penicillins, β-lactam
3.1 Introduction
Microorganisms constitute an inexhaustible reservoir of secondary metabolites with pharmacological, physiological, medical and agricultural applications. The most important commercially exploited secondary metabolite is antibiotics, ...
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