Chapter 8Antimicrobial Peptides from Bacterial Origin: Potential Alternative to Conventional Antibiotics
Lipsy Chopra, Gurdeep Singh, Ramita Taggar, Akanksha Dwivedi, Jitender Nandal, Pradeep Kumar and Debendra K. Sahoo*
Biochemical Engineering Research and Process Development Centre CSIR- Institute of Microbial Technology, Chandigarh, (India)
*Corresponding author: debsahoo@imtech.res.in
Abstract
Antimicrobial resistance (AMR) is a global public health threat in which microorganisms have generated the capacity to tolerate or withstand the impact of antimicrobials. In recent years, studies of antimicrobial peptides (AMPs), biologically active oligopeptides having bioactivity against broad spectrum of microorganism (from viruses to protozoans), have opened a new field of research and widened the application of AMPs which could also be a potential alternative to conventional antibiotics to combat the multiple drug resistant (MDR) pathogens in future. AMPs produced by bacteria are of two types (i) ribosomally synthesized i.e., bacteriocins, (ii) non-ribosomally synthesized. The non-ribosomally synthesized AMPs kill the bacteria by damaging its membrane, which leads to cell death. The ribosomally synthesised bacteriocins are mostly produced by gram-positive and gram-negative bacteria and have antimicrobial activities against similar or closely related bacterial strain(s). This chapter summarizes the current information on classification, mode of action and potential applications ...
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