Methods of Non-a-Amino Acid Synthesis, 2nd Edition

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5

Diastereoselective

and Enantioselective

Syntheses

Most of the syntheses presented in Chapters 1–4 generated achiral amino acids or

chiral, racemic amino acids. A few chiral, nonracemic amino acids were prepared,

but the purpose was to illustrate some specic point of a synthesis. Preparation of

non-α-amino acids using methods that proceed with high diastereoselectivity or

enantioselectivity is very important since any biological activity usually resides in a

single diastereomer, if not a single enantiomer (see Chapter 6 for biologically active

amino acids). The enantioselective methods presented will include the use of chiral

auxiliaries, ...