Methods of Non-a-Amino Acid Synthesis, 2nd Edition

154

Methods of Non-α-Amino Acid Synthesis, Second Edition

drug design, and phosphopeptide mimics have been prepared to target the SH2 domain

of Stat3. Lactam 163 and analogs were examined, and pertinent to this discussion,

they contained ω-amino carboxylic acid units (aminobutanoic, aminopentanoic, and

aminohexanoic acids).

191

Note that POM is pivaloyloxymethyl.

H

N

O

N

O

O

H

N

NH

2

O

O

POM

O

F

F

POM

O

163

Alpha-7 nicotinic acetylcholine receptors (α7 nAChR) are important for the

modulation of many cognitive functions. This observation led to development of α7

nAChR agonists as therapeutic candidates for the treatment of Alzheimer’s disease

and schizophrenia. 5-Am ...