Methods of Non-a-Amino Acid Synthesis, 2nd Edition

124

Methods of Non-α-Amino Acid Synthesis, Second Edition

O NH

2

O

O

H

N

HO

2

C

O OHO

O

O

N

O

O

O

OH

O

O

H

N

CO

2

H

10

9

O NO

O

H

N

MeO

2

C

Ph

Ph

H

2

N(CH

2

)

4

CO

2

H

NEt

3

, DMF

1. HCl, MeOH

2. Tf

2

O, pyridine, DCM

3. Pd(OAc)

2

, BINAP, Cs

2

CO

3

benzophenone imine, THF

cat. HCl, THF/H

2

O

12

11

6.1.2 as substRates FoR PePtides and PRoteins

Non-α-amino acids not only appear as residues in the structure of peptides, but also

serve as substrates for peptides and enzymes. They are incorporated into smaller

molecules that often inhibit the action of proteins or enzymes. A few examples are

presented to show that non-α-amino acids are important in molecules that are tar-

geted by proteins or that target proteins. ...