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Emerging Nanotechnologies for Diagnostics, Drug Delivery and Medical Devices by Abhirup Mandal, Kishore Cholkar, Ashim K Mitra

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Chapter 8

Nanotechnology in Intracellular Trafficking, Imaging, and Delivery of Therapeutic Agents

Animikh Ray, and Ashim K. Mitra     University of Missouri–Kansas City, Kansas City, MO, United States

Abstract

Drug delivery to intracellular compartment is gaining importance as a field of investigation. Many important drugs for various diseases have intracellular organelle as site of action. The anticancer drug doxorubicin acts in the nucleus. Hence it is necessary to design delivery strategies such that the drug will reach its targeted site of action, which often times is located inside the cell. However, there are many challenges to design therapeutic strategies for successful intracellular delivery. Factors such as lysosomal degradation and size ...

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