February 2017
Intermediate to advanced
416 pages
14h 52m
English
book
Emerging Nanotechnologies for Diagnostics, Drug Delivery and Medical Devices
by Ashim K Mitra, Kishore Cholkar, Abhirup Mandal
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Chapter 8
Nanotechnology in Intracellular Trafficking, Imaging, and Delivery of Therapeutic Agents
Animikh Ray, and Ashim K. Mitra University of Missouri–Kansas City, Kansas City, MO, United States
Abstract
Drug delivery to intracellular compartment is gaining importance as a field of investigation. Many important drugs for various diseases have intracellular organelle as site of action. The anticancer drug doxorubicin acts in the nucleus. Hence it is necessary to design delivery strategies such that the drug will reach its targeted site of action, which often times is located inside the cell. However, there are many challenges to design therapeutic strategies for successful intracellular delivery. Factors such as lysosomal degradation and size ...
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