Chapter 12

Solid Lipid Nanoparticles in Drug Delivery

Opportunities and Challenges

Ameya Deshpande, Majrad Mohamed, Saloni B. Daftardar, Meghavi Patel, Sai H.S. Boddu, and Jerry Nesamony     The University of Toledo Health Science Campus, Toledo, OH, United States

Abstract

Since their introduction in the early 1990s, solid lipid nanoparticles (SLNs) have received tremendous attention in drug delivery because of their ability to carry and solubilize lipophilic drugs and their small particle size, resulting in increased cellular uptake and absorption. SLNs are composed of physiological lipids, which reduce the risk of acute and chronic toxicity. However, SLNs are prone to instabilities because of their complex crystallization behavior due to the occurrence ...

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