Chapter 12
Solid Lipid Nanoparticles in Drug Delivery
Opportunities and Challenges
Ameya Deshpande, Majrad Mohamed, Saloni B. Daftardar, Meghavi Patel, Sai H.S. Boddu, and Jerry Nesamony The University of Toledo Health Science Campus, Toledo, OH, United States
Abstract
Since their introduction in the early 1990s, solid lipid nanoparticles (SLNs) have received tremendous attention in drug delivery because of their ability to carry and solubilize lipophilic drugs and their small particle size, resulting in increased cellular uptake and absorption. SLNs are composed of physiological lipids, which reduce the risk of acute and chronic toxicity. However, SLNs are prone to instabilities because of their complex crystallization behavior due to the occurrence ...
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