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Emerging Nanotechnologies for Diagnostics, Drug Delivery and Medical Devices by Abhirup Mandal, Kishore Cholkar, Ashim K Mitra

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Chapter 13

Microneedles in Drug Delivery

Rubi Mahato     Fairleigh Dickinson University, Florham Park, NJ, United States

Abstract

Transdermal drug delivery offers a number of advantages due to its minimally invasive and painless approach as well as the avoidance of first-pass drug metabolism and gastrointestinal degradation. However, most of the transdermal drug delivery systems face the challenges of low drug permeability across the skin. The outermost layer stratum corneum and the entire epidermis pose a significant barrier. To overcome this problem researchers have developed microneedles as therapeutic vehicles to transport drugs across the different layers of skin. After many decades of research, scientists have developed microfabrication technologies ...

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