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Exposure-Response Modeling
book

Exposure-Response Modeling

by Jixian Wang
July 2015
Intermediate to advanced content levelIntermediate to advanced
351 pages
10h 2m
English
Chapman and Hall/CRC
Content preview from Exposure-Response Modeling
90 Exposure-Response Modeling: Methods and Practical Implementation
problems almost surely occur during simulations, leading to a considerable
number of nonconverged runs. The calculation of (4.52) is numerically very
stable and easy to perform. The large sample bias, to gether with the small
sample property assessment, provides useful information for the evaluation of
the SM approach.
We use the combination of the power model and the Emax model to illus-
trate this approach to bias eva luation. Consider the Emax model
y
i
= E
max
/(1 + EC
50
/c
i
) + ε
i
(4.53)
with c
i
given by an power model. For o ur purpose, we estimate c
i
from the
predicted conditional
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Publisher Resources

ISBN: 9781466573215