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Exposure-Response Modeling
book

Exposure-Response Modeling

by Jixian Wang
July 2015
Intermediate to advanced content levelIntermediate to advanced
351 pages
10h 2m
English
Chapman and Hall/CRC
Content preview from Exposure-Response Modeling
Dose–response relationship, dose determination, and adjustment 261
TABLE 9. 1
Asymptotic variances of the estimated dose for target probability equal to
0.3 using Dose–response model (var
dr
) and dose–exposure–response models
(var
der
). P (d = 0 ) is the bas eline pro bability.
P (d = 0) σ
d
var
dr
var
der
0.1 0.1 8.840 12.388
0.1 0.2 2.385 3.148
0.1 0.5 0.745 0.611
0.1 1.0 0.533 0.280
0.2 0.1 2.552 1.896
0.2 0.2 0.937 0.594
0.2 0.5 0.497 0.233
0.2 1.0 0.456 0.204
0.5 0.1 1.917 4.578
0.5 0.2 0.858 1.231
0.5 0.5 0.562 0.360
0.5 1.0 0.560 0.256
wider tha n the dose–exposure mode l based estimates, suggesting instability
with small sample sizes.
TABLE 9. 2
Quantiles of
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Publisher Resources

ISBN: 9781466573215