
Dose–response relationship, dose determination, and adjustment 261
TABLE 9. 1
Asymptotic variances of the estimated dose for target probability equal to
0.3 using Dose–response model (var
dr
) and dose–exposure–response models
(var
der
). P (d = 0 ) is the bas eline pro bability.
P (d = 0) σ
d
var
dr
var
der
0.1 0.1 8.840 12.388
0.1 0.2 2.385 3.148
0.1 0.5 0.745 0.611
0.1 1.0 0.533 0.280
0.2 0.1 2.552 1.896
0.2 0.2 0.937 0.594
0.2 0.5 0.497 0.233
0.2 1.0 0.456 0.204
0.5 0.1 1.917 4.578
0.5 0.2 0.858 1.231
0.5 0.5 0.562 0.360
0.5 1.0 0.560 0.256
wider tha n the dose–exposure mode l based estimates, suggesting instability
with small sample sizes.
TABLE 9. 2
Quantiles of