11.3. Comparing Two Drugs
Bioassay often involves the comparison of two drugs, usually a new drug versus a standard drug. Consider the data in Table 11.2. Researchers studied the effects of the peptides neurotensin and somatostatin in potentiating nonlethal doses of the barbiturate pentobarbital. Groups of mice were administered various dose levels of either neurotensin or somatostatin (Nemeroff et al. 1977; analyzed in Imrey, Koch, and Stokes 1982).
Status | ||||
---|---|---|---|---|
Dose | Drug | Dead | Alive | Total |
0.01 | N | 0 | 30 | 30 |
0.03 | N | 1 | 29 | 30 |
0.10 | N | 1 | 9 | 10 |
0.30 | N | 1 | 9 | 10 |
0.30 | S | 0 | 10 | 10 |
1.00 | N | 4 | 6 | 10 |
1.00 | S | 0 | 10 | 10 |
3.00 | N | 4 | 6 | 10 |
3.00 | S | 1 | 9 | 10 |
10.00 | N | 5 | 5 | 10 |
10.00 | S | 4 | 6 | 10 |
30.00 | S | 5 | 5 | 10 |
30.00 | N | 7 | 3 | 10 |
100.00 | S | 8 | 2 | 10 |
Many times, one drug acts as a dilution of another drug. If this is the case, then the dose response ...
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