11.3. Comparing Two Drugs

Bioassay often involves the comparison of two drugs, usually a new drug versus a standard drug. Consider the data in Table 11.2. Researchers studied the effects of the peptides neurotensin and somatostatin in potentiating nonlethal doses of the barbiturate pentobarbital. Groups of mice were administered various dose levels of either neurotensin or somatostatin (Nemeroff et al. 1977; analyzed in Imrey, Koch, and Stokes 1982).

Table 11.2. N and S Comparison
  Status 
DoseDrugDeadAliveTotal
0.01N03030
0.03N12930
0.10N1910
0.30N1910
0.30S01010
1.00N4610
1.00S01010
3.00N4610
3.00S1910
10.00N5510
10.00S4610
30.00S5510
30.00N7310
100.00S8210

Many times, one drug acts as a dilution of another drug. If this is the case, then the dose response ...

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