Computational Neuroscience

16 Computational Neuroscience: Simulated Demyelinating Neuropathies and Neuronopathies

a high resistance myelin sheath which is an effective insulator of the

internodal axolemma. Most subsequent models of myelinated fi bres

have followed this single cable formulation (e.g., Smith and Koles

1970, Koles and Rasminsky 1972, Schauf and Davis 1974, Waxman

1977, 1978, Waxman and Brill 1978, Waxman et al. 1979, Wood

and Waxman 1982, Wood et al. 1982, Kocsis et al. 1982, Waxman

and Wood 1984, Stephanova 1988a,b,c, 1989a,b, 1990, Quandt and

Davis 1992). In contrast, Blight (1985) represents the internodes as

double cables, with separate potential gradients occurring across

the internodal axolemma and across the myelin sheath, which is

assumed to provide ...