Computational Neuroscience

Simulated Demyelinating Neuropathies and Neuronopathies 63

Fig. 19. During the subthreshold depolarizing current stimuli (+40% of the

threshold), the kinetics of the ionic currents defi ning the depolarizing electrotonic

potential in the normal, ALS1, ALS2 and ALS3 cases is presented at node 10

(a), paranode next to node 10 (b) and mid-internode between nodes 10 and 11

(c). Currents: I

Na

(sodium, dotted lines), I

Kf

(fast potassium, dotted lines), I

Ks

(slow

potassium) I

i

(total ionic) in the node; and I

Na

(sodium, dotted lines), I

Kf

(fast

potassium), I

Ks

(slow potassium), I

i

(total ionic), I

IR

(inward rectifi er), I

Lk

(leakage) in

the illustrated ...