
Simulated Demyelinating Neuropathies and Neuronopathies 63
Fig. 19. During the subthreshold depolarizing current stimuli (+40% of the
threshold), the kinetics of the ionic currents defi ning the depolarizing electrotonic
potential in the normal, ALS1, ALS2 and ALS3 cases is presented at node 10
(a), paranode next to node 10 (b) and mid-internode between nodes 10 and 11
(c). Currents: I
Na
(sodium, dotted lines), I
Kf
(fast potassium, dotted lines), I
Ks
(slow
potassium) I
i
(total ionic) in the node; and I
Na
(sodium, dotted lines), I
Kf
(fast
potassium), I
Ks
(slow potassium), I
i
(total ionic), I
IR
(inward rectifi er), I
Lk
(leakage) in
the illustrated ...