January 2013
Intermediate to advanced
148 pages
4h 22m
English
Content preview from Computational Neuroscience
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28 Computational Neuroscience: Simulated Demyelinating Neuropathies and Neuronopathies
The multi-layered model, without or with taking into account the
aqueous layers within the myelin sheath, is used for human motor
nerve fi bres in normal and pathological cases, such as in simulated
cases of uniform axonal dysfunctions or in simulated cases of
internodal, paranodal and simultaneously of paranodal internodal
demyelinations, each of them systematic or focal. A given reduction
of the myelin lamellae (defi ning internodal demyelination), or of
the paranodal seal resistance (defi ning paranodal demyelination),
or simultaneously both of them (defi ning paranodal internodal
demyelination) is uniform along the fi bre length for the systematically
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