
16 Current Trends in Bayesian Methodology with Applications
characterizes the quantity of tracer which would be found at a site in the br ain
in a steady-state regime obtained in the large time limit in a hypothetical
exp e riment in which the tracer concentration in plasma is maintained at a
constant level. In order to do this it is necessary to develop appropria te mod-
els for the process a nd, owing to the complexity of the problem at hand, to
consider both parameter estimation and model selection/averaging.
1.4.2 Background
Compartmental models [35] are widely used in the modelling of PET. Such
models describe the system of interest, in this case ...