
18
Multi-State Models for Disease Natural
History
Amy E. Laird
Oregon Health & Science Un iversity
Rebecca A. Hubbard
University of Washington
Lurdes Y. T. Inoue
University of Washington
CONTENTS
18.1 Intro ductio n . . . . . . . . .. . . . . . .. .. . . . . . .. . . .. . . . .. . . .. . . . .. .. . . . .. .. . 367
18.2 Multi-State Models: Background and Notation . . .. .. . . . . . .. . . .. 368
18.2.1 Markov processes . . . .. .. .. . . . .. . . .. . . . . . .. .. . . . . . .. . . . . . . 369
18.2.2 Markov renewal processes and semi-Markov pr ocesses . . 370
18.3 Estimation and Inference: A Review . . . . . .. .. . . . . . .. . . . . . . . .. . . .. 372 ...