Electrochemical Biosensors

November 11, 2014 15:47 PSP Book - 9in x 6in 01-Serge-Cosnier-c01

Electrochemical Detection of Exocytosis 31

treatment and reliability of the extracted data do not necessarily

benefit from decreasing the electrode size below a certain threshold.

In that sense, using a single nanoelectrode for amperometrically

monitoring exocytosis at isolated cells could be limited by the

distortion of the amperometric spikes induced by a partial collection

of the vesicular content described above. Conversely, its excellent

S/N ratio would obviously allow detection of some very small

important events (PSs, stand-alone feet, etc.). However, several

potential difficulties ...