November 11, 2014 15:51 PSP Book - 9in x 6in 07-Serge-Cosnier-c07
Chapter 7
Electrochemical DNA Sensors Based on
Nanoparticles
Claudio Parolo, Alfredo de la Escosura-Mu
˜
niz,
and Arben Merkoc¸i
Nanobioelectronics and Biosensors Group, Institut Catal
`
a de Nanotecnologia,
CIN2 (ICN–CSIC), Barcelona 08193, Spain
ICREA, Instituci
´
o Catalana de Recerca i Estudis Avanc¸ats, Barcelona 08010, Spain
arben.merkoci@icn.cat
7.1 Introduction
The identification/quantification of specific DNA sequences is of
crucial importance for many fields. For example, the detection of
DNA mutations is already correlated to specific diseases. The most
frequent of these mutations are single-nucleotide polymorphisms
(SNPs), the change of just one base in a DNA sequence that can
provoke serious ...