Electrochemical Biosensors

November 11, 2014 15:51 PSP Book - 9in x 6in 07-Serge-Cosnier-c07

210 Electrochemical DNA Sensors Based on Nanoparticles

Also Liu et al. [45] developed a DNA hybridization biosensor

based on hollow gold nanospheres prepared using Co NPs as

sacrificial templates (Fig. 7.5b). After the immobilization of the

hollow gold nanospheres onto the gold electrode, the authors

functionalized them with capture ssDNA to detect the hybridization

events. A limit of detection of 1 pM was achieved with a range of

detection between 1 pM and 10 nM, measuring cyclic voltammetry

and differential pulse voltammetry of Co(phen)

3

3+

, which has a high

affinity for dsDNA and not for ...