June 2013
Intermediate to advanced
1088 pages
40h 48m
English
book
23rd European Symposium on Computer Aided Process Engineering
by Andrzej Kraslawski, Ilkka Turunen
Content preview from 23rd European Symposium on Computer Aided Process Engineering
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A combination of experiments and molecular dynamics simulation for the investigation of the ion-exchange adsorption of biological macromolecules
Juan Liang and Georg Fieg, Institute of Process and Plant Engineering, Hamburg University of Technology, Schwarzenbergstrasse 95, 21073 Hamburg, Germany
Abstract
To get a comprehensive understanding of the adsorption of macromolecules onto ion-exchange adsorbent, the single component ion-exchange adsorptions of serum albumin and hemoglobin onto Q Sepharose FF were investigated with both adsorption equilibrium experiments and molecular dynamics (MD) simulations. Both of the investigations show that serum albumin adsorbs stronger than hemoglobin in the condition studied. The steric mass-action model ...
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