Biomaterials for Bone Regeneration

358 Biomaterials for Bone Regeneration

in their strong tendency to aggregate. Therefore low degrees of modi cation

are crucial and low concentrations are advisable. This aggregation tendency

may, however, become bene cial in some other applications. For example,

when mixed in appropriate concentrations and proportions, some of our

modi ed polysaccharides also showed the ability to self-organize in water

to form stable nanospheres. Unfortunately, both the components and their

concentrations have to be adjusted experimentally, which is a laborious and

time-consuming procedure.

11.3 Processing techniques

Although the component materials of the carrier determine its properties

to a large extent, the preparation methodology is another ...