Biomaterials for Bone Regeneration

362 Biomaterials for Bone Regeneration

To solve the problems connected with achieving suf cient encapsulation

ef ciency and carrier stability, some supplementary procedures have been

created which follow nanocarrier fabrication.

Liposomes, for example, can be stabilized by modifying their surface with

short PEG chains. Such vesicles are known as ‘stealth’ liposomes, as this

modi cation not only stabilizes the nanocarrier, but also ‘hides’ it from the

immunological system of the human body. As a result, their circulation life-

times are much longer. Another solution also applied by our group is to coat

liposomes with ultrathin mono- or multilayer polymeric  lms. This stabilizes

liposomes, but also limits the leaking of the drug from the ...