Biomaterials for Bone Regeneration

Applications of SMPs in mechanobiology and bone repair 125

Dalby et al ., 2007) (Fig. 5.4b). Recently, it was shown that cells cultured on

typical  at tissue culture polystyrene, and then moved to a topographic sub-

strate, improved the neurogenic differentiation of human pluripotent stem

cells (Chan et al ., 2013). This study motivates the design of SMP substrates

with the ability to transition from a  at topography to a nanotopography. For

both expanding and topography changing substrates, the substrates could

be used to precisely control the time during culture that a mechanical dif-

ferentiation stimulus is applied. It is possible that this control may result in

osteogenic differentiation that is improved over chemical induction alone ...