June 2014
Intermediate to advanced
502 pages
17h 39m
English
Content preview from Biomaterials for Bone Regeneration
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Potential of electromagnetic and ultrasound stimulations 453
In the present chapter, a gelatin-based cryogel was combined with physi-
cal stimuli in order to develop tissue-engineering constructs enabling bone
repair. The results clearly indicated that the physical stimuli resulted in the
upregulation of ECM proteins.
Elaborating an idea of Castner and Ratner (2002), we physically enhanced
the coating of gelatin with osteoblasts and with ECM: we followed a particu-
lar biomimetic strategy whereby the seeded cells built a new biocompatible
surface over the biomaterial, making it very useful for the biointegration.
The idea of Castner and Ratner and a discussion of the concept of bio-
compatibility follow. When a biomaterial is implanted ...
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