March 2015
Intermediate to advanced
476 pages
22h 5m
English
Content preview from Electromagnetic Fields in Biology and Medicine
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170 Electromagnetic Fields in Biology and Medicine
Mouse Cytokine 20-Plex Panel technology allowed us to detect the expression of 20 different
cytokines simultaneously in a single peripheral blood and brain tissue sample. Analysis results
demonstrate that single intraperitoneal LPS injection results in long-lasting changes of cytokine
expression in the peripheral blood. The major proinammatory cytokine TNF-α was upregu-
lated in sham animals, at 14 and 21days after LPS injections. Initially decreased expression at
7days (as compared to control expression) is in agreement with the knowledge about the bipha-
sic character of LPS-induced changes, when after completion of acute phase, TNF-α release by
macrophages is reduced below normal values, ...
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