March 2015
Intermediate to advanced
476 pages
22h 5m
English
Content preview from Electromagnetic Fields in Biology and Medicine
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263Physical Regulation in Cartilage and Bone Repair
In adult sheep, a signicant osteointegration of autologous osteochondral implants was seen as
well as an improved cartilaginous integration in the animals treated with the I-ONE therapy. The
synovial liquid, removed at the end of the treatment from the control animals, contained higher
levels of IL-1β and TNF-α and a lower concentration of TGF-β compared to the animals treated
with the I-ONE therapy.
With this, the antidegenerative, reparative, and anti-inammatory effects of treatment with
I-ONE therapy can be accounted for also in vivo.
16.3.2 clinical usE of BiopHysical stimulation on a
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