March 2015
Intermediate to advanced
476 pages
22h 5m
English
Content preview from Electromagnetic Fields in Biology and Medicine
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405Electroporation for Electrochemotherapy and Gene Therapy
Recently, clinical studies performed in patients with melanoma, as well as in veterinary patients,
show great promise for further development of this therapy.
135,136
In human clinical study, 24
patients with malignant melanoma subcutaneous metastases were treated three times. The response
to therapy was observed in treated as well as in distant nontreated tumor nodules. In 53% of patients,
a systemic response was observed resulting in either stable disease or an OR. The major adverse
side effect was transient pain after the application of electric pulses. In posttreatment biopsies, ...
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