
227Age-Dependent Magnetic Sensitivity of Brain and Heart Tissues
as a result of cAMP-dependent Ca
2+
pump activation in SR membrane (Brini and Carafoli, 2009).
Age-dependent weakening of cGMP-dependent Ca
2+
efux from the cells through both Ca
2+
pump
and Na
+
/Ca
2+
exchange in forward mode can be considered as a consequence of dysfunction of
cGMP formation process. SMF-induced elevation of [cGMP]
i
leads to the activation of Ca
2+
efux,
which is more pronounced in cells of older rats’ tissues that are rich in high [Ca
2+
]
i
(Ayrapetyan
et al., 1994, 2005).
Considering the presented data, the conclusion that intracellular Ca
2+
has a multifunctional role ...