November 2018
Intermediate to advanced
272 pages
6h 51m
Japanese
book
エレガントなSciPy ―Pythonによる科学技術計算
by Juan Nunez-Iglesias, Stéfan van der Walt, Harriet Dashnow, 山崎 邦子, 山崎 康宏
Content preview from エレガントなSciPy ―Pythonによる科学技術計算
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46
2 章 NumPy と SciPy を用いた分位数正規化
遺伝子発現プロファイルのクラスタリングにより、図
2-4
が示すように、悪性黒色腫のハイリ
スクなサブタイプ（クラスタ
2
）が同定されたようです。この主張は、より頑健なクラスタリング
と統計的検定を行った
TCGA
の元研究によっても裏付けられています。これは実際のところ、こ
のような結果を示した最新の研究にすぎず、他にも白血病（血液がん）や腸のがんを含む様々なが
んのサブタイプを同定した研究があります。上記のクラスタリング手法はかなり脆弱ですが、同様
なデータセットを探索するための、もっと頑健な手法もあります
†
。■
2.5.1
追加の課題：
TCGA
の患者クラスタを使用する
我々のクラスタは、原論文で使われたクラスタよりもうまく生存率の予測ができるでしょうか。
紫外線の影響はどうでしょう。原論文のクラスタと紫外線の影響を表したデータ列を使って、生存
率曲線をプロットしてみましょう。我々のクラスタの結果と比較してみてください。
†
The Cancer Genome Atlas Network, "Genomic Classification of Cutaneous Melanoma"
（
http://dx.doi.org/10.1016/
j.cell.2015.05.044
）
, Cell 161, no. 7 (2015):1681--1696.
生存時間（年）
クラスタ1
クラスタ2
クラスタ3
図
2-4
遺伝子発現データを基にクラスタリングした、患者の生存率曲線 ...
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O’Reilly covers everything we've got, with content to help us build a world-class technology community, upgrade the capabilities and competencies of our teams, and improve overall team performance as well as their engagement.Julian F.
I wanted to learn C and C++, but it didn't click for me until I picked up an O'Reilly book. When I went on the O’Reilly platform, I was astonished to find all the books there, plus live events and sandboxes so you could play around with the technology.Addison B.
I’ve been on the O’Reilly platform for more than eight years. I use a couple of learning platforms, but I'm on O'Reilly more than anybody else. When you're there, you start learning. I'm never disappointed.Amir M.
I'm always learning. So when I got on to O'Reilly, I was like a kid in a candy store. There are playlists. There are answers. There's on-demand training. It's worth its weight in gold, in terms of what it allows me to do.