Statistics and Data Analysis for Microarrays Using R and Bioconductor, 2nd Edition

Contents

List of Figures xxv

List of Tables xxxv

Preface xxxix

1 Introduction 1

1.1 Bioinformatics – an emerging discipline . . . . . . . . . . . . 1

2 The cell and its basic mechanisms 5

2.1 The cell . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5

2.2 The building blocks of genomic information . . . . . . . . . . 13

2.2.1 The deoxyribonucleic acid (DNA) . . . . . . . . . . . 13

2.2.2 The DNA as a language . . . . . . . . . . . . . . . . . 19

2.2.3 Erro rs in the DNA language . . . . . . . . . . . . . . . 23

2.2.4 Other useful concepts . . . . . . . . . . . . . . . . . . 24

2.3 Expression of gene tic information . . . . . . . . . . . . .