April 2016
Beginner to intermediate
1036 pages
33h 39m
English
book
Statistics and Data Analysis for Microarrays Using R and Bioconductor, 2nd Edition
by Sorin Draghici
Content preview from Statistics and Data Analysis for Microarrays Using R and Bioconductor, 2nd Edition
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Chapter 4
Reliabili ty and reproducibility issues
in DNA microarr ay measurements
If reproducibility may be a problem, conduct the test only once.
—Velilind’s Laws of Experimentation
4.1 Introduction
Since its intro duction approximatively 15 years ago [37 4], the DNA microarray
technology has evolved rapidly.
1
However, microarray results are still marred
by several technical issues that are often neglected. This chapter will survey
and in some cases expose the most relevant issues.
Although DNA microarrays are all based on the same fundamental princi-
ple of the complementary hybridization of nucleic acid strands, the available
1
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