April 2016
Beginner to intermediate
1036 pages
33h 39m
English
book
Statistics and Data Analysis for Microarrays Using R and Bioconductor, 2nd Edition
by Sorin Draghici
Content preview from Statistics and Data Analysis for Microarrays Using R and Bioconductor, 2nd Edition
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Chapter 23
Functional analys is and biological
interpret ation of microarray da t a
There are no facts, only interpretations.
—Friedrich Wilhelm Nietzsche
23.1 Over-representation analysis (ORA)
The availability of GO and many cross-refer e nc ing databases seems to solve
the problem of interpreting the results of a microarray experiment fro m a bio-
logical point of view. Most database s provide efficient search mechanisms that
return quickly all annota tion information associated to any specific gene or
gene product of interest. However, the problem is that most relevant databases
are oriented towards a manual, gene by g e ne querying. If the proce ssing ...
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