Statistics and Data Analysis for Microarrays Using R and Bioconductor, 2nd Edition

Cluster analysis 615

identified by the standard one-way clustering algorithms. A bicluster can be

defined as a subset of genes that are correlated under a subset of samples.

Biclustering has been used in several a pplications such as clustering microarray

data [293], identifying protein interactions [280], co llaborative filtering [170],

and text mining [76].

To illustrate the concept of biclustering, a simple example is shown in Fig-

ure 18.31. In this figure, the expression levels of thre e genes across 10 samples

are shown. Considering all of the sa mples, it is difficult to observe any corre-

lation between the three genes as shown in Figure 18.31(a). ...