High Performance Polymers, 2nd Edition

2: POLY( p-XYLYLENE)S 59

Figure 2.15 Nanocalorimeter [118].

There is a great interest in developing calorime-

try devices, and in particular, ultra-miniature

microcalorimeter devices that require only small vol-

umes of sampled media and that can quickly measure a

large number of reactions. Ideally, those reaction mea-

surements can provide efficient assays, e.g., inhibitor

assays which can be used in high throughput screening

to screen roughly 100,000 test ligands a day.

Such nanocalorimeter arrays typically containa thin

parylene coating of 1–3 µm that is deposited over the

detectors and the frame. Sample droplets are placed

directly onto the parylene