61Nanomaterial Cell Interactions in Tissue Engineering
One of the most important advantages of using SA peptide molecules as sub-
strate is that they can be decorated with bioactive sequences, such as cell adhe-
sion and stimulating factors. Besides having nanobrillar structure, the presence of
active sequences stimulates cells in a similar way that ECM matrix does. The cyto-
compatibility of SA peptide–polymer conjugate (DGRFFF–PEG3000) containing
the RGD sequence as the cell attachment factor was evaluated by Castelletto etal.
(2013). They prepared β-sheet SA, core–shell bril formation with a bril width
of 73 ± 1nm and DGRFFF–PEG3000 lms at low concentration. They observed
that these structures enhanced corneal broblast proliferation. ...