
134 Cell and Material Interface
(b) (c)
(a)
mmetric stabilisation
of microtubules
Anisotropic tension
centrosome off-centred
Microtubules rerouting
Tension equilibrat
centrosome centred
spreading
Contractility+
Straight edges
Contractility++
Adhesion-free edge
Contractility+++
Low spreading
Contractility–
Key
(A)
ECM micropattern
Stress fiber
Branched meshwork
Vinculin
F-actin
Filament bundle
FIGURE 5.17 (A) Variation in cell and cell contractility with change in adhesion area.
(Adapted from Thery, M. etal., Cell Motil. Cytoskel., 63, 341, 2006.) (B) Cytoskeletal remod-
eling also results in orientation of microtubules within the cell. (From Thery