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10
Macrophage-Mediated
Foreign Body Responses
Vladimir Riabov, Alexandru Gudima,
and Julia Kzhyshkowska
10.1 MACROPHAGE ORIGIN AND SUBPOPULATIONS
IN TISSUES IN HOMEOSTASIS
Currently, most of the available information about origins of macrophages comes
from murine studies utilizing genetic fate-mapping techniques. F4/80+ cells rst
appear in mouse yolk sac on the days 8–9 of embryo development, and then popu-
late embryonic liver at day 10, reaching the peak at days 12–14 of development [1].
Yolk sac macrophages differentiate from restricted progenitors that give rise to mac-
rophages and red blood cells, whereas fetal liver macrophages differentiate ...