152 Cell and Material Interface
6.2.2 protEin immobilization at tHE cEll–scaFFold intErFacE
Polymeric scaffolds can be made more suitable for cell attachment and growth by
surface modication. Various peptide sequences derived from ECM molecules such
as vitronectin, laminin, collagen, and brinogen have also been used to mediate cell
attachment (LeBaron and Athanisou, 2000). Among these, laminin 332 (formerly
termed laminin 5) is of special interest for skin tissue engineering since it is the
major component of the basement membrane of skin, synthesized by keratinocytes
for attachment. Its interaction with integrins plays important roles in the adhesion,
proliferation, and migration of skin cells (Tsuruta et al., 2008). Recently, it was