
220 Cell and Material Interface
CHI/ELR-RGDcapsules.
39
Various cellular/material interactions are enhanced when
chemically modied polysaccharides are used as a component of LbL lms.
Other approaches include the chemical cross-linking of the lms to improve cell
adhesion. On hyaluronan containing lms, Picart etal. employed the EDC (1-ethyl-
3-[3-dimethylaminopropyl]carbodiimide hydrochloride) chemistry to increase the
stiffness of the lms. They observed an enhancement on myoblast cell attachment
on the stiffer lms.
32,40
They also employed the EDC chemistry on CHI/HA lms
and observed an enhancement in myoblast adhesion, although not as pronounced ...