66 Cell and Material Interface
graft (Takabayashi etal., 2015). Nanoparticle-PRP system was reported to stimulate
epithelialization and angiogenesis of wound effectively compared to particle-free
formulation and control group. In a similar study, electropositive and RGD pep-
tide functionalized chitosan and electronegative chondroitin sulfate were complexed
into nanoparticles with a net positive charge (150–200nm range, 20 mV) for use in
wound healing by promoting adhesion and migration of skin cells (Hansson etal.,
2012). Human dermal broblasts were adhered on the surface effectively by their cell
area that was increased three times due to the enhanced cell–nanoparticle interaction
and stimulation of cells by RGD sequence. In addition, ...