book

Medicinal Chemistry, 2nd Edition

by D. Sriram, P. Yogeeswari

May 2010

Intermediate to advanced

712 pages

18h 30m

English

Pearson India

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1.1 Introduction1.2 How are the New Drugs Discovered?1.3 Requirements for an Investigational Drug to be Tested in Human Volunteers1.4 How are the Investigational Drugs Tested in Humans?1.5 How Does Testing Continue after a New Drug is Approved?1.6 Procedures Followed in Drug DesignFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
2.1 Introduction2.2 Functional Group Review2.3 Stereochemistry2.4 Acid-Base Chemistry2.5 Biologically Significant Nitrogen-Containing Compounds2.6 Physicochemical Properties and Drug Action2.7 Bioisosteric Replacement2.8 Drug-Receptor Bonding2.9 G Protein-Coupled ReceptorsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
3.1 Drug Metabolism3.2 ProdrugsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
4.1 Introduction4.2 Cadd Methodology4.3 Small Molecule-Based Drug Design4.4 Macromolecule-Based Drug Design4.5 Substituent Constants Useful for Qsar AnalysisFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
5.1 Introduction—Anaesthesia and its Stages5.2 Mechanism of Action5.3 Classification5.4 Inhalation Anaesthetics (Synthesis, Uses, and Dose)5.5 Intravenous Anaesthetics (Synthesis, Uses, and Dose)5.6 Newer DrugsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
6.1 Introduction6.2 Ideal Properties of Local Anaesthetics6.3 Mechanism of Action6.4 Clinical Uses of Local Anaesthetics6.5 Classification of Local Anaesthetics6.6 Structures, Synthesis, and Structure-Activity Relationship (Sar) of Benzoic Acid Derivatives6.7 Structures, Synthesis, and Sar of P-Aminobenzoic Acid Derivatives6.8 Structures, Synthesis, and Sar of Anilides6.9 Miscellaneous6.10 Newer DrugsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions

7.1 Introduction7.2 Classification of Sedative and Hypnotics7.3 Barbiturates7.4 Benzodiazepines7.5 Benzodiazepine Antagonists7.6 Miscellaneous7.7 Anxiolytic Agents7.8 Newer DrugsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
8.1 Introduction: Epilepsy and Types of Seizures8.2 Classification8.3 Structural Requirements for Anticonvulsant Agents and Their Structure-Activity Relationship8.4 Hydantoins8.5 Oxazolidinediones8.6 Succinimides8.7 Benzodiazepines8.8 Gaba Analogues8.9 Miscellaneous8.10 Newer AnticonvulsantsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
9.1 Introduction9.2 Typical or Classical Antipsychotic Agents: Synthesis, Mechanism of Action, and Sar9.3 Atypical Antipsychotic Agents9.4 Newer DrugsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
10.1 Introduction10.2 Classification10.3 Mechanism of Action10.4 Side-Effects of Classical Antidepressants10.5 Monoamino Oxidase (Mao) Inhibitors10.6 Tricyclic Antidepressants10.7 Atypical Antidepressants10.8 Miscellaneous Drugs10.9 Newer DrugsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
11.1 Introduction11.2 Mechanism of Action11.3 Pharmacophore Requirement11.4 Clinical Uses11.5 Classification11.6 Morphine and its Derivatives11.7 Phenyl (Ethyl) Piperidines11.8 Diphenyl Heptanones11.9 Benzazocin (Benzomorphan) Derivatives11.10 Narcotic Antagonists11.11 Newer DrugsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
12.1 Introduction12.2 Classification12.3 Biosynthesis of Eicosanoids12.4 Mechanism of Anti-Inflammatory Action12.5 Side-Effects12.6 Salicylic Acid Derivatives12.7 P-Aminophenol Derivatives12.8 Pyrazolidinedione Derivatives12.9 Anthranilic Acid Derivatives (Fenamates)12.10 Aryl Alkanoic Acid Derivatives12.11 Oxicams12.12 SAR (Structure Activity Relationship of Oxicams)12.13 Miscellaneous Drugs12.14 Anti-Gout Drugs12.15 Selective Cox-2 Inhibitors12.16 Newer DrugsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
13.1 Anti-Parkinsonism Agents13.2 Muscle Relaxants13.3 Drugs for Alzheimer’s Disease Treatment13.4 CNS Stimulants13.5 Newer DrugsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
14.1 Introduction14.2 H1 Receptor Antagonist14.3 H2 Receptor Antagonist14.4 Histamine H3 Receptors14.5 Histamine H4 Receptors14.6 Proton Pump Inhibitors14.7 Newer DrugsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
15.1 Introduction15.2 Uses15.3 Classification15.4 Osmotic Diuretics15.5 Carbonic Anhydrase Inhibitors15.6 Thiazide Diuretics15.7 Potassium-Sparing Diuretics15.8 Loop Diuretics15.9 Miscellaneous Drugs15.10 Newer DrugsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
16.1 Introduction16.2 Classification16.3 Peripheral Anti-Adrenergic Drugs16.4 Centrally Acting Antihypertensive Drugs16.5 Direct Vasodilators16.6 Ganglionic Blocking Agents16.7 β-Adrenergic Blockers16.8 Calcium Channel Blockers16.9 Angiotensin-Converting Enzyme (Ace) Inhibitors16.10 Angiotensin II Antagonists (At2 Antagonists)16.11 Miscellaneous Drugs16.12 Newer DrugsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
17.1 Introduction17.2 Classification17.3 Class II Agents17.4 Class III AgentsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
18.1 Introduction18.2 Classification18.3 Hmg-Coa Reductase Inhibitors (Statins)18.4 Aryloxyisobutyric Acid Derivatives (Fibrates)18.5 Miscellaneous Drugs18.6 Newer DrugsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
19.1 Introduction19.2 Classification19.3 Nitrates/Nitrites19.4 β-Adrenergic Blockers19.5 Calcium Channel Blockers19.6 Miscellaneous Drugs19.7 Newer DrugsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
20.1 Introduction20.2 Insulin20.3 Oral Hypoglycaemic Agents Classification20.4 Strategy For Controlling Hyperglycaemia20.5 Sulphonyl Ureas20.6 Biguanides20.7 Substituted Benzoic Acid Derivatives (Meglitinides)20.8 Thiazolidinediones20.9 Miscellaneous Drugs20.10 Newer DrugsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
21.1 Introduction21.2 Classification21.3 Coumarin Derivatives21.4 Indanedione Derivatives21.5 Newer DrugsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
22.1 Introduction22.2 Sympathomimetic Drugs22.3 Sympathetic (Adrenergic) Blocking Agents (Sympatholytics)22.4 Newer DrugsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
23.1 Introduction23.2 Cholinomimetics23.3 Anticholinesterases23.4 Cholinergic Blocking Agents (Antimuscarinic Drugs)23.5 Newer DrugsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
24.1 Sulphonamides24.2 Sulphones24.3 Dihydrofolate reductase (DHFR) Inhibitors24.4 Newer DrugFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
25.1 Introduction25.2 Structures of Fluoroquinolones25.3 Mechanism of Action25.4 Uses25.5 Classification25.6 SAR of Quinolones25.7 Adverse Effects25.8 Synthesis of Fluoroquinolones25.9 Newer DrugsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
26.1 β-Lactam Antibiotics26.2 Tetracycline Antibiotics26.3 Macrolide Antibiotics26.4 Aminoglycoside Antibiotics26.5 Miscellaneous Antibiotics26.6 Newer DrugsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
27.1 Introduction27.2 Mechanisms of ActionFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
28.1 Introduction28.2 Classification28.3 Antifungal Antibiotics28.4 Azole Antifungals28.5 Pyrimidine Derivatives28.6 Miscellaneous Agents28.7 Newer DrugsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
29.1 Anti-HIV Agents29.2 Anti-Herpes Simplex Virus (HSV) Agents29.3 Miscellaneous Agents29.4 Newer DrugsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
30.1 Introduction30.2 Antiamoebic Agents30.3 Antimalarial Agents30.4 Anthelmintics30.5 Miscellaneous Antiprotozoal Drugs30.6 Newer DrugFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
31.1 Introduction31.2 Limitations of Therapy31.3 Classification31.4 Alkylating Agents31.5 Antimetabolites31.6 Anticancer Antibiotics31.7 Miscellaneous Drugs31.8 Anticancer Plant Products31.9 Hormones and their Antagonists31.10 Miscellaneous Drugs31.11 Newer DrugsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
32.1 Introduction32.2 Functions of Prostaglandins32.3 Biosynthesis of Prostaglandins32.4 Nomenclature32.5 Structures of Therapeutically useful Prostaglandins32.6 Sar of ProstaglandinsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
33.1 Introduction33.2 Biosynthesis of Steroid Hormones33.3 Overall Mechanism of Action of Steroid Hormones33.4 Oestrogens33.5 Progestins33.6 Androgens33.7 GlucocorticoidsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
34.1 Anti-Obesity Drugs34.2 Pde-5 Inhibitors for Male Erectile Dysfunction (Ed)34.3 Anti-Migraine Drugs34.4 Anti-Asthmatics34.5 Thyroid and Anti-Thyroid Drugs34.6 Anti-Platelet Drugs (Antithrombotics)34.7 Immunopharmacological Drugs34.8 Anti-Cough and Expectorants34.9 Diagnostic Agents34.10 Antiseptics and Disinfectants34.11 Some Important Antiseptics and Disinfectants34.12 Pharmaceutical Aid34.13 VitaminsFurther ReadingsMultiple Choice QuestionsQuestionsSolution to Multiple Choice Questions
35.1 Introduction35.2 General Rules35.3 Heterocyclic Compounds35.4 ExamplesFurther ReadingsQuestions

Overview

The second edition of Medicinal Chemistry is based on the core module of pharmacy syllabi of various technical universities, and targets undergraduate B.Pharma students across India. The current edition has been designed by authors based on the opinion of the experts to include the latest developments in the field of medicinal chemistry, detailed synthesis mechanism of the drugs and their mode of action inside the body.