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Medicinal Chemistry, 2nd Edition by P. Yogeeswari, D. Sriram

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Chapter 21

Oral Anticoagulants

LEARNING OBJECTIVES
  • Describe clotting of blood and its significance

  • Define anticoagulants and their utility

  • Classify anticoagulants based on the chemical structure

  • Discuss the mode of action of anticoagulants

  • Discuss the synthetic protocol of various anticoagulants

  • List some new anticoagulants

21.1 INTRODUCTION

The coagulation of blood is a complex process during which blood forms solid clots. It is an important part of haemostasis whereby a damaged blood vessel wall is covered by a fibrin clot to stop haemorrhage and aid repair of the damaged vessel. Disorders in coagulation can lead to increased haemorrhage and/or thrombosis and embolism.

Blood coagulation process requires coagulation factors, calcium ...

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